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KMID : 0377519900150010001
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Chung-Ang Journal of Medicine
1990 Volume.15 No. 1 p.1 ~ p.8
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Effects of Vanadate on the Electrical Activity of Smooth Muscle Cells of the Pyloric Antrum
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Abstract
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Effects of vanadate on the resting membrane potential and slow waves of the circular smooth muscle were observed using glass capillary microelectrodes. The obtained results were as follows:
1. Vanadate did not show any effects on the slow waves of spontaneously beating preparations.
2. Variation of the resting membrane potential due to the change of outside K+ was 20-28m V/decade
which suggested the significant contribution of Na´ to maintain the resting membrane potential.
3. Vanadate did not show any further effects on the depolarized state about 10mV by outside 20mM
K+
4. Vanadate induced the depolarization in the low outside K+ condition and the effect was exaggerated when Ca´ was depleted.
5. Vanadate induced the depolarization in the low Na´ and K+ condition.
It was conjectured that the effects of vanadate were enhancing the voltage-dependent calcium.
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